Academia Open
Vol 9 No 2 (2024): December
Clinical Research

The Study On Antioxidant And Anti-Inflammatory Effects Of Sodium Copper Chlorophyllin In Male Rats Receiving Indomethacin


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  • Ibrahim H. Muslim*,
  • Nadheerah F. Neamah,
  • Falah H. Shari
Ibrahim H. Muslim
Pharmacology &Toxicology Department, College of Pharmacy, University of Basrah, Basrah, Iraq *
Nadheerah F. Neamah
Pharmacology &Toxicology Department, College of Pharmacy, University of Basrah, Basrah, Iraq
Falah H. Shari
University of Maaqal, Iraq

(*) Corresponding Author
Picture in here are illustration from public domain image or provided by the author, as part of their works
DOI: https://doi.org/10.21070/acopen.9.2024.9223
Published July 7, 2024
Keywords
  • Sodium copper chlorophyllin,
  • antioxidant,
  • anti-inflammatory,
  • indomethacin,
  • oxidative stress
How to Cite
Muslim, I. H., Neamah, N. F., & Shari, F. H. (2024). The Study On Antioxidant And Anti-Inflammatory Effects Of Sodium Copper Chlorophyllin In Male Rats Receiving Indomethacin. Academia Open, 9(2), DOI 10.21070/acopen.9.2024.9223. https://doi.org/10.21070/acopen.9.2024.9223

Copyright (c) 2024 Ibrahim H. Muslim, Nadheerah F. Neamah, Falah H. Shari

Creative Commons License

This work is licensed under a Creative Commons Attribution 4.0 International License.

Abstract

Sodium copper chlorophyllin (SC-C) is widely used for its biological properties and color. This study evaluated SC-C's antioxidative and anti-inflammatory effects in male rats treated with indomethacin. Fifty rats were divided into five groups: control, indomethacin, rabeprazole, and two SC-C dosages (35 mg/kg and 70 mg/kg). Indomethacin reduced serum GPx levels, but rabeprazole and SC-C treatments restored them. MDA levels increased with indomethacin but normalized with other treatments. Indomethacin also lowered IL-10, IL-4, and TNF, which returned to normal in treated groups. Histopathology showed SC-C reversed liver damage from indomethacin. SC-C demonstrates strong antioxidant and anti-inflammatory activities, suggesting its potential as a therapeutic agent.

Highlight:

 

  1. SC-C significantly restores serum GPx levels reduced by indomethacin.
  2. SC-C normalizes MDA, IL-10, IL-4, and TNF levels, countering oxidative stress.
  3. Histopathology shows SC-C reverses liver damage induced by indomethacin.

 

Key wards: Sodium copper chlorophyllin, antioxidant, anti-inflammatory, indomethacin, oxidative stress

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